High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification - Nutrition et obésités: approches systémiques (UMR-S 1269)
Article Dans Une Revue Biochimie Année : 2020

High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification

Résumé

It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
Fichier principal
Vignette du fichier
Revue Biochimie 25062020 ZA-NV_ID.pdf (410.08 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02902650 , version 1 (06-03-2024)

Identifiants

Citer

Isabelle Dugail, Ez-Zoubir Amri, Nicolas Vitale. High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification. Biochimie, 2020, 179, pp.257-265. ⟨10.1016/j.biochi.2020.07.001⟩. ⟨hal-02902650⟩
167 Consultations
48 Téléchargements

Altmetric

Partager

More