Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation - Bordeaux Population Health Accéder directement au contenu
Article Dans Une Revue Kidney International Année : 2021

Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation

Ivana Juric
  • Fonction : Auteur
Chen-Shan Chin
  • Fonction : Auteur
Morgan E. Grams

Résumé

Although the gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR), little is known about GFR trajectories after transplantation, their determinants, and their association with outcomes. To evaluate these parameters we examined kidney transplant recipients receiving care at 15 academic centers. Patients underwent prospective monitoring of estimated GFR (eGFR) measurements, with assessment of clinical, functional, histological and immunological parameters. Additional validation took place in seven randomized controlled trials that included a total of 14,132 patients with 403,497 eGFR measurements. After a median follow-up of 6.5 years, 1,688 patients developed end-stage kidney disease. Using unsupervised latent class mixed models, we identified eight distinct eGFR trajectories. Multinomial regression models identified seven significant determinants of eGFR trajectories including donor age, eGFR, proteinuria, and several significant histological features: graft scarring, graft interstitial inflammation and tubulitis, microcirculation inflammation, and circulating anti-HLA donor specific antibodies. The eGFR trajectories were associated with progression to end stage kidney disease. These trajectories, their determinants and respective associations with end stage kidney disease were similar across cohorts, as well as in diverse clinical scenarios, therapeutic eras and in the seven randomized control trials. Thus, our results provide the basis for a trajectory-based assessment of kidney transplant patients for risk stratification and monitoring.
Fichier principal
Vignette du fichier
S0085253820309376.pdf (1.98 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03493946 , version 1 (02-01-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Marc Raynaud, Olivier Aubert, Peter P. Reese, Yassine Bouatou, Maarten Naesens, et al.. Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation. Kidney International, 2021, 99, pp.186 - 197. ⟨10.1016/j.kint.2020.07.025⟩. ⟨hal-03493946⟩
73 Consultations
129 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More