Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Molecular Nutrition and Food Research Année : 2008

Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells.

Résumé

Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.
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Dates et versions

hal-00281570 , version 1 (09-06-2008)

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Citer

Anna-Kristina Marel, Gérard Lizard, Jean-Claude Izard, Norbert Latruffe, Dominique Delmas. Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells.. Molecular Nutrition and Food Research, 2008, 52 (5), pp.538-48. ⟨10.1002/mnfr.200700185⟩. ⟨hal-00281570⟩
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