Intranasal immunization of mice with vp2 DNA of human rotavirus a induces cellular and humoral immunity. - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Acta virologica. English ed. Année : 2008

Intranasal immunization of mice with vp2 DNA of human rotavirus a induces cellular and humoral immunity.

Résumé

DNA vaccination using a plasmid encoding Human rotavirus A (HuRV-A) inner capsid VP2 was examined in a mouse model. BALB/c mice were immunized intranasally (i.n.) with a VP2 DNA vaccine that induced cellular and humoral immune response to HuRV-A. The increased levels of cytokines IFN-gamma and IL-4 and the production of anti-VP2 IgG antibodies were detected. In addition, splenocyte proliferation detected by MTT test was enhanced in the mice treated with the vaccine. These results may encourage the development of a HuRV-A DNA vaccine derived from the inner layer of viral capsid that can be administered i.n. Key words: Human rotavirus A; VP2 protein; immunogenicity; DNA vaccine; mouse.

Domaines

Virologie
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Dates et versions

hal-00510663 , version 1 (20-08-2010)

Identifiants

  • HAL Id : hal-00510663 , version 1
  • PUBMED : 19143478

Citer

F. Pourasgari, S. Ahmadian, Z. M. Hassan, M. Mahdavi, A. H. Salmanian M N, et al.. Intranasal immunization of mice with vp2 DNA of human rotavirus a induces cellular and humoral immunity.. Acta virologica. English ed., 2008, 52 (4), pp.225-9. ⟨hal-00510663⟩
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