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Article Dans Une Revue Acta Ophthalmologica Année : 2014

Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests.

Résumé

Purpose: To determine whether tear osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case-control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a tear osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), tear osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, tear osmolarity was not modified in these selected CL wearers. The yield of tear osmolarity with TearLab™ in assessing ocular surface disorders in CL wearers deserves further investigation.

Dates et versions

hal-01069203 , version 1 (28-09-2014)

Identifiants

Citer

Aurore Muselier-Mathieu, Alain Bron, Bénigne Mathieu, Maxime Souchier, Françoise Brignole-Baudouin, et al.. Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests.. Acta Ophthalmologica, 2014, 92 (4), pp.364-369. ⟨10.1111/aos.12103⟩. ⟨hal-01069203⟩
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