%0 Journal Article %T DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool %+ Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB) %+ Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB) %+ Conception, synthèse et vectorisation de biomolécules. (CSVB) %A Diabate, Pape Diaba %A Laguerre, Aurélien %A Pirrotta, Marc %A Desbois, Nicolas %A Boudon, Julien %A Gros, Claude P. %A Monchaud, David %< avec comité de lecture %@ 1144-0546 %J New Journal of Chemistry %I Royal Society of Chemistry %V 40 %N 7 %P 5683 - 5689 %8 2016-05-10 %D 2016 %R 10.1039/c6nj01012a %K energy-transfer %K dye-complexes %K ligands %K rna %K aggregation %K recognition %K selectivity %K porphyrin %K cells %K visualization %Z Chemical SciencesJournal articles %X The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd.TEGPy: its efficiency as quadruplex-selective fluorescent dye relies on a structural design that endows it with attractive supramolecular and electronic properties and makes it an efficient turn-on, quadruplex-selective fluorescent stain thanks to a DNA-mediated sensitization mechanism that ensures a high level of specificity. %G English %L hal-01427995 %U https://u-bourgogne.hal.science/hal-01427995 %~ UNIV-PARIS5 %~ UNIV-BOURGOGNE %~ CNRS %~ ICB %~ ICMUB %~ FNCLCC %~ CURIE %~ INC-CNRS %~ PSL %~ USPC %~ UNIV-PARIS %~ INSTITUT-CURIE-PSL %~ TEST2-HALCNRS %~ TEST3-HALCNRS