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Article Dans Une Revue Archives of cardiovascular diseases Année : 2017

Implications of excess weight in the cardiotoxicity of anthracyclines and trastuzumab in breast cancer

Résumé

Anthracyclines are anticancer agents with a broad spectrum of activity in oncological practice. However, the use of anthracyclines is limited by the cardiotoxicity they may induce [1]. Following the administration of anthracyclines in the setting of adjuvant therapy for breast cancer, trastuzumab (Herceptin), a humanized monoclonal antibody against the human epidermal growth factor receptor 2 (HER 2) protein, is effective in patients that overexpress this receptor [1]. The addition of trastuzumab therapy to sequential anthracycline and taxane adjuvant treatment reduced the risk of breast cancer recurrence by nearly one-half, and the risk of death by one-third [2]. However, while preclinical studies did not reveal cardiotoxicity, later clinical studies showed that treatment with trastuzumab led to an unexpected incidence of cardiac side-effects [3]. The most frequent effect was reduced systolic ventricular function, asymptomatic or associated with heart failure.

Dates et versions

hal-01528637 , version 1 (29-05-2017)

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Charles Guenancia, Sylvain Ladoire, François Ghiringelli, Luc Rochette, Catherine Vergely, et al.. Implications of excess weight in the cardiotoxicity of anthracyclines and trastuzumab in breast cancer. Archives of cardiovascular diseases, 2017, 110 (2), pp.69 - 71. ⟨10.1016/j.acvd.2016.12.004⟩. ⟨hal-01528637⟩
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