%0 Journal Article %T Immune stimulation during chemotherapy increases incidence of acute graft versus host disease in acute myeloid leukemia: A study on behalf of SFGM-TC and ALFA %+ Service d'hématologie greffe [Saint-Louis] %+ Shanghai Jiao Tong University [Shanghai] %+ Shanghai Institute of Hematology %+ Hôpital Saint-Louis %+ Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] %+ CHU Lille %+ Département d'hématologie [Gustave Roussy] %+ Université Paris-Saclay %+ Institut Gustave Roussy (IGR) %+ CHU Pitié-Salpêtrière [AP-HP] %+ Institut d'Hématologie de Basse-Normandie (IHBN) %+ Service d'Hématologie [CHRU Besançon] %+ CHU Dijon %+ Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges] %+ Hôpital Haut-Lévêque [CHU Bordeaux] %+ Hôpital Haut-Lévêque %+ Service Hématologie - IUCT-Oncopole [CHU Toulouse] %+ Hôpital d'Instruction des Armées Percy %+ Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel) %+ Centre méditerranéen de médecine moléculaire (C3M) %A Wang, Lining %A Raffoux, Emmanuel %A Thomas, Xavier %A Yakoub-Agha, Ibrahim %A Bouhris, Jean-Henri %A de Botton, Stéphane %A Michallet, Mauricette %A Quoc, Stéphanie Nguyen %A Chantepie, Sylvain %A Deconinck, Eric %A Caillot, Denis %A Turlure, Pascal %A Vigouroux, Stéphane %A Pigneux, Arnaud %A Huynh, Anne %A Malfuson, Jean-Valère %A Loschi, Michael %A Socie, Gerard %A Dombret, Hervé %A de La Tour, Régis Peffault %A Cluzeau, Thomas %Z IF 2.501 %< avec comité de lecture %@ 0145-2126 %J Leukemia Research %I Elsevier %V 54 %P 12-16 %8 2017-03 %D 2017 %R 10.1016/j.leukres.2017.01.002 %M 28088653 %K AML %K GVHD %K Infections %K Toxicities %K Transplantation %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Human health and pathology/HematologyJournal articles %X 60-70% of AML patients have an indication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their treatment. Graft versus host disease (GvHD), the major cause of mortality and comorbidities post-transplantation, develops by immunological mechanism and decides greatly prognosis and quality of life (QoL) of graft recipient. Current GvHD prophylaxis is not personalized. Infections, toxicities and leukemic infiltration complicate the first chemotherapy phases prior to allo-HSCT. They, to certain extent, induce local immune stimulation. Impact of immune stimulation of this period on incidence of GvHD has not been evaluated. We retrospectively studied 238 AML patients transplanted at first remission from 21 French centers in the ALFA-0702 protocol and found that cutaneous and digestive immune stimulation during induction increases the incidence of skin and gut aGVHD, respectively. Furthermore, prolonged febrile duration correlates with elevated incidence of grade II-IV aGvHD. Thus, we identified a group of patients with higher risk of aGvHD. The benefit of personalized GvHD prophylaxis should be explored in a prospective cohort to decrease incidence of aGvHD in these patients and improve their QoLs. %G English %L hal-01557470 %U https://u-bourgogne.hal.science/hal-01557470 %~ SSA %~ UNICE %~ UNIV-PARIS7 %~ UNIV-BOURGOGNE %~ HCL %~ APHP %~ CHLS %~ FNCLCC %~ IGR %~ BACLESSE %~ BECQUEREL %~ COMUE-NORMANDIE %~ USPC %~ UNIV-PARIS-SACLAY %~ LNC-UMR866 %~ LNC-SAPHIHR %~ IGR-SACLAY %~ UNIV-COTEDAZUR %~ UNICAEN %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ ALLIANCE-SU %~ C3M