Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin - Université de Bourgogne Accéder directement au contenu
Communication Dans Un Congrès Année : 2011

Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin

Résumé

The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to weaning exposure of rats to the phytoestrogen genistein (G) and/or the antiandrogen vinclozolin (V) at 1 mg/kg-d, alone or in association. Using several approaches, we found that G- and GV-exposed rats displayed significantly greater epithelial branching and proliferation, wider terminal end buds than controls at PND35, as well as ductal hyperplasia and periductal fibrosis. Focal branching defects were present in V-exposed rats. An increased ER and AR expression was observed in G- and CV- as compared to V-exposed rats at PND35. Surprisingly, a significant number of CV- and to a lesser extent. V-exposed animals displayed abnormal hyperplasic alveolar structures at PND50. Thus, gestational and lactational exposure to low doses of genistein plus vinclozolin may seriously affect peripubertal development of the rat mammary gland.
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Dates et versions

hal-01594405 , version 1 (26-09-2017)

Identifiants

  • HAL Id : hal-01594405 , version 1
  • PRODINRA : 367936

Citer

Saad H. El Sheikh, Geri Meduri, Pascal Phrakonkham, Raymond Berges, S. Vacher, et al.. Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin. Cancéropole île de France, Nov 2011, Paris, France. 1 p. ⟨hal-01594405⟩
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