Because maximal voluntary strength of the knee extensor muscles can be facilitated by the concomitant application of neuromuscular electrical stimulation (NMES) to the contralateral homologous muscle, we aimed to determine whether this was associated with an enhanced neural drive to the agonist muscles. A secondary goal of this study was to examine the potential dose-response relationship between NMES intensity and contralateral facilitation. Twelve healthy men (age: 30 ± 7 yr) completed several maximal voluntary contractions (MVC) of the left knee extensors while the right quadriceps received low-intensity NMES (10% MVC), high-intensity NMES (30% MVC) or no NMES. Supramaximal paired stimuli were delivered to the left quadriceps muscle during and immediately after the MVCs to assess voluntary activation. The EMG activity of vastus lateralis (VL) and biceps femoris (BF) was recorded. MVC torque, voluntary activation and VL EMG activity were higher for both low-intensity and high-intensity NMES compared to no NMES (P < .05), with no difference between the two NMES conditions. The acute application of NMES to the right quadriceps facilitated MVC strength of the contralateral homonymous muscle by enhancing its efferent neural drive. No evident dose-response relationship between NMES intensity and contralateral facilitation was observed.