%0 Journal Article %T Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency %+ Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL) %+ Lipides - Nutrition - Cancer [Dijon - U1231] (LNC) %+ Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124) %A Aires, Virginie %A Delmas, Dominique %A Djouadi, Fatima %A Bastin, Jean %A Cherkaoui-Malki, Mustapha %A Latruffe, Norbert %Z IF 2.861 %< avec comité de lecture %@ 1420-3049 %J Molecules %I MDPI %V 23 %N 1 %P 7 %8 2018-01 %D 2018 %R 10.3390/molecules23010007 %M 29271911 %K CPT2-deficient cells %K miRNA level %K resveratrol %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X Carnitine palmitoyltransferase-2 (CPT2) is a mitochondrial enzyme involved in long-chain fatty acid entry into mitochondria for their β-oxidation and energy production. Two phenotypes are associated with the extremely reduced CPT2 activity in genetically deficient patients: neonatal lethality or, in milder forms, myopathy. Resveratrol (RSV) is a phytophenol produced by grape plant in response to biotic or abiotic stresses that displays anti-oxidant properties, in particular through AP-1, NFκB, STAT-3, and COX pathways. Some beneficiary effects of RSV are due to its modulation of microRNA (miRNA) expression. RSV can enhance residual CPT2 activities in human fibroblasts derived from CPT2-deficient patients and restores normal fatty acid oxidation rates likely through stimulation of mitochondrial biogenesis. Here, we report changes in miRNA expression linked to CPT2-deficiency, and we identify miRNAs whose expression changed following RSV treatment of control or CPT2-deficient fibroblasts isolated from patients. Our findings suggest that RSV consumption might exert beneficiary effects in patients with CPT2-deficiency. %G English %L hal-01685832 %U https://u-bourgogne.hal.science/hal-01685832 %~ UNIV-PARIS5 %~ UNIV-BOURGOGNE %~ CNRS %~ USPC %~ LNC-UMR866 %~ AGREENIUM %~ BOIPEROXIL %~ LNC-CADIR %~ UNIV-PARIS %~ UP-SCIENCES %~ TEST3-HALCNRS %~ INSTITUT-AGRO