%0 Journal Article %T LPCAT2 controls chemoresistance in colorectal cancer %+ Lipides - Nutrition - Cancer [Dijon - U1231] (LNC) %+ Equipe CADIR (LNC - U1231) %+ Département d'oncologie médicale [Centre Georges-François Leclerc] %A Cotte, Alexia Karen %A Aires, Virginie %A Ghiringhelli, François %A Delmas, Dominique %< avec comité de lecture %@ 2372-3556 %J Molecular & Cellular Oncology %I Taylor et Francis %V 5 %N 3 %P e1448245 %8 2018 %D 2018 %R 10.1080/23723556.2018.1448245 %K colorectal cancer %K chemoresistance %K immunogenic cell death %K Lipid droplets %K LPCAT2 %Z Life Sciences [q-bio]/CancerJournal articles %X Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation. %G English %L hal-01820220 %U https://u-bourgogne.hal.science/hal-01820220 %~ UNIV-BOURGOGNE %~ FNCLCC %~ CGFL %~ LNC-UMR866 %~ AGREENIUM %~ LNC-CADIR