%0 Book Section %T Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions. %+ Département d'oncologie médicale [Centre Georges-François Leclerc] %+ Lipides - Nutrition - Cancer [Dijon - U1231] (LNC) %+ Université Bourgogne Franche-Comté [COMUE] (UBFC) %+ Plateforme de transfert en biologie cancérologique [Dijon] %A Chalmin, Fanny %A Humblin, Etienne %A Ghiringhelli, François %A Vegran, Frédérique %B International Review of Cell and Molecular Biology %V 341 %P 1-61 %8 2018-08-20 %D 2018 %R 10.1016/bs.ircmb.2018.07.002 %M 30262030 %K Cytokines %K STAT %K T CD4 lymphocytes %K Transcription factors %K Transcriptional network %Z Life Sciences [q-bio]/CancerBook sections %X Understanding the basis of cellular differentiation is a fundamental issue in developmental biology but also for the comprehension of pathological processes. In fact, the palette of developmental decisions for naive CD4 T cells is a critical aspect of the development of appropriate immune responses which could control infectious processes or cancer growth. However, the current accumulation of data on CD4 T cells biology reveals a complex world with different helper populations. Naive CD4 T cells can differentiate into different subtypes in response to cytokine stimulation. This stimulation involves a complex transcriptional network implicating the activation of Signal Transducer and Activator of Transcription but also master regulator transcription factors allowing the functions of each helper T lymphocyte subtype. In this review, we will present an overview of the transcriptional regulation which controls process of helper T cells differentiation. We will focus on the role of initiator transcriptional factors and on master regulators but also on other nonspecific transcriptional factors which refine the T helper polarization to stabilize or modulate the differentiation program. %G English %L hal-01915895 %U https://u-bourgogne.hal.science/hal-01915895 %~ UNIV-BOURGOGNE %~ FNCLCC %~ CGFL %~ LNC-UMR866 %~ AGREENIUM %~ LNC-CADIR %~ DEESSE