%0 Journal Article %T Exercise stress CMR reveals reduced aortic distensibility and impaired right-ventricular adaptation to exercise in patients with repaired tetralogy of Fallot %+ Centre de résonance magnétique biologique et médicale (CRMBM) %+ AP-HM, Pôle d'imagerie médicale, Hôpital de la Timone, CEMEREM, Marseille, France %+ Département de Cardiologie [Hôpital de la Timone - APHM] %+ Service de Chirurgie vasculaire (Hôpital de la Timone adultes) %+ Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon) %+ Laboratoire d'Electronique, d'Informatique et d'Image [EA 7508] (Le2i) %A Habert, Paul %A Bentatou, Zakarya %A Aldebert, Philippe %A Finas, Mathieu %A Bartoli, Axel %A Bal, Laurence %A Lalande, Alain %A Rapacchi, Stanislas %A Guye, Maxime %A Kober, Frank %A Bernard, Monique %A Jacquier, Alexis %Z Hospital clinical research program n° 2014-A00354-43 %Z Direction generale de l'offre de soin (DGOS) %< avec comité de lecture %@ 1932-6203 %J PLoS ONE %I Public Library of Science %V 13 %N 12 %P e0208749 %8 2018-12-31 %D 2018 %R 10.1371/journal.pone.0208749 %K Pulmonary Valve-Replacement %K Congenital Heart-Disease %K Rate-Pressure Product %K Physical-Exercise %K Stroke Volume %K Arterial Stiffness %K Ascending Aorta %K Cardiac Mri %K Regurgitation %K Treadmill %Z Engineering Sciences [physics] %Z Life Sciences [q-bio]/BioengineeringJournal articles %X The aim of our study was to evaluate the feasibility of exercise cardiac magnetic resonance (CMR) in patients with repaired tetralogy of Fallot (RTOF) and to assess right and left ventricular adaptation and aortic wall response to exercise in comparison with volunteers.Methods11 RTOF and 11 volunteers underwent prospective CMR at rest and during exercise. A supine bicycle ergometer was employed to reach twice the resting heart rate during continuous exercise, blood pressure and heart rate were recorded. Bi-ventricular parameters and aortic stiffness were assessed using accelerated cine sequences and flow-encoding CMR. A t-test was used to compare values between groups. A Mann Whitney test was used to compare values within groups.ResultsIn RTOF both ventricles showed an impaired contractile reserve (RVEF rest 36.2 +/- 8.3%, +1.3 +/- 3.9% increase after exercise; LVEF rest 53.8 +/- 6.1%, +5.7 +/- 6.4% increase after exercise) compared to volunteers (RVEF rest 50.5 +/- 5.0%, +10.4 +/- 7.1% increase after exercise, p = 0.039; LVEF rest 61.9 +/- 3.1%, +12.2 +/- 4.7% increase after exercise, p = 0.014).RTOF showed a reduced distensibility of the ascending aorta during exercise compared to volunteers (RTOF: 3.4 +/- 1.9 10-3.mmHg(-1)vs volunteers: 5.1 +/- 1.4 10-3.mmHg(-1); p = 0.027). Ascending aorta distensibility was correlated to cardiac work in the volunteers but not in RTOF.ConclusionRTOF showed an impaired contractile reserve for both ventricles. The exercise unmasked a reduced distensibility of the ascending aorta in RTOF, which may be an early sign of increased aortic rigidity. %G English %2 https://u-bourgogne.hal.science/hal-01998022/document %2 https://u-bourgogne.hal.science/hal-01998022/file/journal.pone.0208749.pdf %L hal-01998022 %U https://u-bourgogne.hal.science/hal-01998022 %~ UNIV-BOURGOGNE %~ CNRS %~ UNIV-AMU %~ UNIV-BM %~ ENSAM %~ CRMBM %~ LE2I %~ UNIV-BM-THESE %~ IMVIA %~ IFTIM %~ ARTS-ET-METIERS-SCIENCES-ET-TECHNOLOGIES %~ TEST3-HALCNRS %~ HESAM %~ HESAM-ENSAM