Lens status and macular pigment optical density in an old French population (MONTRACHET's study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases) - Université de Bourgogne Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Lens status and macular pigment optical density in an old French population (MONTRACHET's study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases)

Résumé

The aim of our study was to compare macular pigment optical density between pkakic and pseudophakic eyes in a population‐based study in the elderly. Methods The hree city study (3C) included 9294 participants aged 65 years or more from three cities (Bordeaux, Dijon and Montpellier) in 1999. After a 10‐year follow‐up, Dijon's cohort had a complete ophthalmic examination in the MONTRACHET study; 1153 participants older than 75 years were included. Every participant had fundus photographs, macular pigment optical density measured by two‐wavelength autofluorescence. We retained only one eye for each subject, the one with the best image quality. An experimented investigator recorded macular pigment optical density at 0.5, 1, 2, and 6° eccentricity and classified images into one of the three patterns: no ring, ringlike or intermediate. Subjects with age‐related macular degeneration were excluded. Results We included 534 participants with good image quality. The age was 82.3 ± 3.7 years. There were 247 (46.3%) phakic and 287 (53.7%) pseudophakic. Mean macular pigment optical density was significantly higher in pseudophakic eyes at 0.5° (0.66 ± 0.25 vs 0.44 ± 0.23 density units) at 1° (0.56 ± 0.21 vs 0.39 ± 0.19 density units) at 2° (0.35 ± 0.14 vs 0.25 ± 0.13 density units) and at 6° (0.08 ± 0.04 vs 0.06 ± 0.04 density units), p < 0,0001. There were no significant differences of macular pigment pattern between whatever the lens status (p = 0.64). Conclusions Macular pigment optical density measurement by two‐wavelength autofluorescence is dependent on the lens status so that it should be taken into account when used in elderly where cataractarct surgery is common.
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hal-02740540 , version 1 (02-06-2020)

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Olivier Fleck, Philippe Koehrer, Seydou Alassane, Christine Binquet, Lionel Brétillon, et al.. Lens status and macular pigment optical density in an old French population (MONTRACHET's study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases). European Association for Vision and Eye Research (EVER) Congress, Oct 2015, Nice, France. 1 p., ⟨10.1111/j.1755-3768.2015.0460⟩. ⟨hal-02740540⟩
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