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Article Dans Une Revue Organic Letters Année : 2020

Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1 H)-one-based Heterocycles

Résumé

A simple and effective biocompatible domino reaction triggered by a model protease and leading to the formation of strongly fluorescent quinoxalin-2(1H)-one N-heterocycles is described. Some positive attributes including versatility and the ability to provide outstanding fluorescence “OFF–ON” responses were revealed by this work. They open the way for practical applications of this novel type of “covalent-assembly”-based fluorescent probe in the fields of sensing and bioimaging.

Domaines

Chimie
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Dates et versions

hal-03016953 , version 1 (20-11-2020)

Identifiants

Citer

Garance Dejouy, Kévin Renault, Quentin Bonnin, Arnaud Chevalier, Cédric Michaudet, et al.. Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1 H)-one-based Heterocycles. Organic Letters, 2020, 22 (16), pp.6494-6499. ⟨10.26434/chemrxiv.12613862.v1⟩. ⟨hal-03016953⟩
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