%0 Journal Article
%T Influence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry
%+ Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2)
%A Graber, Mathilde
%A Garnier, Lucie
%A Mohr, Sophie
%A Delpont, Benoit
%A Blanc-Labarre, Christelle
%A Vergely, Catherine
%A Giroud, Maurice
%A Béjot, Yannick
%< avec comité de lecture
%@ 0251-5350
%J Neuroepidemiology
%I Karger
%V 54
%N 6
%P 490-497
%8 2020-12-15
%D 2020
%R 10.1159/000497614
%Z Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemJournal articles
%X Objective: We assessed the association between pre-stroke cognitive status and 90-day case-fatality. Methods: Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Association between pre-stroke cognitive status and case-fatality at 90 days was evaluated using Cox regression. Results: Seven hundred sixty-two patients were identified, and information about pre-stroke cognitive status was obtained for 716 (92.6%) of them, including 603 IS (84.2%) and 113 ICH (15.8%). Before stroke, 99 (13.8%) patients had mild cognitive impairment (MCI) and 98 (13.7%) had dementia. Patients with cognitive impairment were older, had a higher prevalence of several risk factors, more severe stroke, more frequent ICH, and less admission to stroke unit. Case-fatality rate at 90 days was 11.7% in patients without cognitive impairment, 32.3% in MCI patients, and 55.1% in patients with dementia. In multivariable analyses, pre-existing MCI (hazard ratio [HR] 2.22, 95% CI 1.21–4.05, p = 0.009) and dementia (HR 4.35, 95% CI 2.49–7.61, p < 0.001) were both associated with 90-day case-fatality. Conclusion: Pre-stroke MCI and dementia were both associated with increased mortality. These associations were not fully explained by baseline characteristics, pre-stroke dependency, stroke severity or patient management, and underlying reasons need to be investigated.
%G English
%L hal-03416918
%U https://u-bourgogne.hal.science/hal-03416918
%~ UNIV-BOURGOGNE
%~ CARDIO
%~ PEC2