Bleomycin for Percutaneous Sclerotherapy of Venous and Lymphatic Malformations: A Retrospective Study of Safety, Efficacy and Mid-Term Outcomes in 26 Patients - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Medicine Année : 2021

Bleomycin for Percutaneous Sclerotherapy of Venous and Lymphatic Malformations: A Retrospective Study of Safety, Efficacy and Mid-Term Outcomes in 26 Patients

Franck Nevesny
  • Fonction : Auteur
Olivier Chevallier
Nicolas Falvo
  • Fonction : Auteur
Kévin Guillen
Alexandre Malakhia
  • Fonction : Auteur
Julie Pellegrinelli
  • Fonction : Auteur
Pierre-Olivier Comby
Bertille Bonniaud
  • Fonction : Auteur
Romaric Loffroy

Résumé

Percutaneous sclerotherapy is used to treat venous and lymphatic vascular malformations, which can cause significant discomfort and/or disfigurement. The purpose of this study is to describe the bleomycin sclerotherapy technique and to evaluate its clinical and radiological efficacy and safety. We retrospectively identified consecutive patients with venous malformations (VMs) and lymphatic malformations (LMs) who underwent bleomycin sclerotherapy in 2011–2020 at our institution. We collected the clinical and radiological success rates, complications and recurrences separately in the VM and LM groups. We identified 26 patients, 15 with VMs and 11 with LMs. The significant volume reductions obtained were 45% in the VM group and 76% in the LM group (p = 0.003 and p = 0.009, respectively). Significant reductions in discomfort/pain and in cosmetic disfigurement were obtained in both groups. An overall improvement was reported by 69% and 82% of patients in the VM and LM groups, respectively. No major complications occurred during the mean follow-up of 51 ± 34 months in the VM group and 29 ± 18 months in the LM group. A recurrence developed within 2 years in 23% of patients. Bleomycin is clinically and radiologically effective for the treatment of venous and lymphatic malformations, with a high level of patient safety.

Dates et versions

hal-03613358 , version 1 (18-03-2022)

Identifiants

Citer

Franck Nevesny, Olivier Chevallier, Nicolas Falvo, Kévin Guillen, Alexandre Malakhia, et al.. Bleomycin for Percutaneous Sclerotherapy of Venous and Lymphatic Malformations: A Retrospective Study of Safety, Efficacy and Mid-Term Outcomes in 26 Patients. Journal of Clinical Medicine, 2021, 10 (6), pp.1302. ⟨10.3390/jcm10061302⟩. ⟨hal-03613358⟩
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