Relevant Biological Effects of Varicocele Embolization with N-Butyl Cyanoacrylate Glue on Semen Parameters in Infertile Men - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Biomedicines Année : 2021

Relevant Biological Effects of Varicocele Embolization with N-Butyl Cyanoacrylate Glue on Semen Parameters in Infertile Men

Olivier Chevallier
Patricia Fauque
Carole Poncelet
  • Fonction : Auteur
Kévin Guillen
Pierre-Olivier Comby
Karine Astruc
  • Fonction : Auteur
Julie Barberet
Nicolas Falvo
  • Fonction : Auteur
Emmanuel Simon
  • Fonction : Auteur
Romaric Loffroy

Résumé

Surgical treatment or varicocele embolization (VE) with sclerosing or mechanical embolic agents have been shown to improve the semen parameters of infertile men. The aim of this study was to evaluate the impact of VE using N-butyl cyanoacrylate (NBCA) glue on semen parameters in infertile men. From January 2014 to June 2018, infertile adult patients with stage 3 varicocele and an initial semen analysis showing at least one abnormal semen parameter, and who were successfully embolized with NBCA Glubran®2 glue, were retrospectively recruited. The availability of a second semen analysis after VE was mandatory for patient inclusion. The primary endpoint was the change in total sperm number (TSN) after VE. The other parameters of interest were progressive and total sperm motilities (Smot) at 1 h (H1), sperm vitality (SV) and morphology (SMor). One hundred and two patients were included. Eight patients presented null TSN before and after VE. Among the remaining 94 patients, a significant improvement in the median TSN after VE was shown (31.79 × 106/ejaculate [IQR: 11.10–127.40 × 106/ejaculate] versus 62.24 × 106/ejaculate [IQR: 17.90–201.60 × 106/ejaculate], p = 0.0295). Significant improvement in TSN was found for the 60 oligo- or azoospermic patients (p = 0.0007), whereas no significant change was found for the 42 patients with normal initial TSN (p = 0.49). Other parameters, such as progressive and total SMot, SV and SMor, also significantly improved after VE (p = 0.0003, 0.0013, 0.0356 and 0.007, respectively). The use of NBCA glue as an embolic agent for VE in infertile men with stage 3 varicocele significantly improves the semen parameters.

Dates et versions

hal-03617618 , version 1 (23-03-2022)

Identifiants

Citer

Olivier Chevallier, Patricia Fauque, Carole Poncelet, Kévin Guillen, Pierre-Olivier Comby, et al.. Relevant Biological Effects of Varicocele Embolization with N-Butyl Cyanoacrylate Glue on Semen Parameters in Infertile Men. Biomedicines, 2021, 9 (10), pp.1423. ⟨10.3390/biomedicines9101423⟩. ⟨hal-03617618⟩
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