The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept
Résumé
One of the challenges to improve radiotherapy is to increase cancer· cells radiosensit ivity. Using nanocarriers, concentration of chemotherapy drugs into cancer cells could be improved. Titanate nanotubes (TiONts) presented Interesting properties as needle shape, large specific surface, many hydroxide groups at physiological pH. These particularities could be useful for their interactions with the cellular environment while they increase the possibilities of grafting. The interest of TiONts associated with ·radiotherapy was evaluated in radioresistant human glioblastoma cell lines in an in vitro model.