The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Radiotherapy & Oncology Année : 2012

The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept

Céline Mirjolet
  • Fonction : Auteur
Anne-Laure Papa
  • Fonction : Auteur
Gilles Créhange
  • Fonction : Auteur
Julien Boudon
Olivier Raguin
  • Fonction : Auteur
Cédric Seignez
  • Fonction : Auteur
Catherine Paul
  • Fonction : Auteur
Gilles Truc
  • Fonction : Auteur
Nadine Millot
Philippe Maingon
  • Fonction : Auteur

Résumé

One of the challenges to improve radiotherapy is to increase cancer· cells radiosensit ivity. Using nanocarriers, concentration of chemotherapy drugs into cancer cells could be improved. Titanate nanotubes (TiONts) presented Interesting properties as needle shape, large specific surface, many hydroxide groups at physiological pH. These particularities could be useful for their interactions with the cellular environment while they increase the possibilities of grafting. The interest of TiONts associated with ·radiotherapy was evaluated in radioresistant human glioblastoma cell lines in an in vitro model.

Domaines

Chimie Cancer
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Dates et versions

hal-03792958 , version 1 (30-09-2022)

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Citer

Céline Mirjolet, Anne-Laure Papa, Gilles Créhange, Julien Boudon, Olivier Raguin, et al.. The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept. Radiotherapy & Oncology, 2012, 104, pp.24. ⟨10.1016/S0167-8140(15)34565-5⟩. ⟨hal-03792958⟩

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