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Article Dans Une Revue Journal of Biomedical Optics Année : 2016

Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats

Résumé

The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast time-gated diffuse optical tomography exploiting Mellin–Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550  μM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability.

Domaines

Imagerie

Dates et versions

hal-01281208 , version 1 (01-03-2016)

Identifiants

Citer

Laura Di Sieno, Georges Bettega, Michel Berger, Cynthia Hamou, Marion Aribert, et al.. Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats. Journal of Biomedical Optics, 2016, 21 (2), pp.025004 ⟨10.1117/1.JBO.21.2.025004⟩. ⟨hal-01281208⟩
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