INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY
Résumé
During cardiac arrhythmia, functional reentries may take the form of spiral waves. The purpose of this study was to induce spiral waves by an electrical stimulation of cultured neonatal rat cardiomyocytes using a microelectrode arrays technology. In basal conditions, cardiac muscle cells in monolayer culture displayed a planar wavefront propagation. External electrical impulse trains induced severe arrhythmia and spiral waves appeared. This in vitro generation of spiral wave opens a new way to test the anti-arrhythmic drugs and for strategies at microscopically scale.
Domaines
Mathématiques [math] Systèmes dynamiques [math.DS] Science non linéaire [physics] Dynamique Chaotique [nlin.CD] Sciences de l'ingénieur [physics] Traitement du signal et de l'image [eess.SP] Informatique [cs] Traitement du signal et de l'image [eess.SP] Sciences du Vivant [q-bio] Médecine humaine et pathologie Cardiologie et système cardiovasculaire
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