Heavy + light chain analysis to assign myeloma response is analogous to the IMWG response criteria
Guillemette Fouquet
(1)
,
Kym Ie Snell
(2)
,
Stephanie Guidez
(3)
,
Susanna Schraen
(4)
,
Eileen Boyle
(1)
,
Loïc Renaud
(1)
,
Déborah Desmier
(3)
,
Antoine Machet
(5)
,
Niels Moya
(6, 3)
,
Thomas Systchenko
(7)
,
Cécile Gruchet
(6, 3)
,
Olivier Decaux
(8, 9)
,
Bertrand Arnulf
(10)
,
Cécile Fohrer
(11)
,
Valentine Richez
(6, 3)
,
Brigitte Kolb
(12)
,
Margaret Macro
(13)
,
Lionel Karlin
(14)
,
Bruno Royer
(15)
,
Brigitte Pegourie
(16)
,
Benjamin Hebraud
(11)
,
Denis Caillot
(17)
,
Aurore Perrot
(18)
,
Philippe Moreau
(19)
,
Thierry Facon
(1)
,
Hervé Avet-Loiseau
(11)
,
Thomas Dejoie
(19)
,
Cyrille Hulin
(20)
,
Stephen Harding
,
Xavier Leleu
(6, 3)
1
Hôpital Claude Huriez [Lille]
2 University of Birmingham [Birmingham]
3 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
4 Pôle de Biologie Pathologie Génétique [CHU Lille]
5 Hôpital de Hautepierre [Strasbourg]
6 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
7 Hôpital Côte de Nacre [CHU Caen]
8 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
9 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
10 Hôpital Saint-Louis
11 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
12 Hôpital Robert Debré
13 Hôpital Universitaire de Caen
14 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
15 CHU Amiens-Picardie
16 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
17 CHU Dijon
18 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
19 Hôtel-Dieu de Nantes
20 Hôpital Haut-Lévêque [CHU Bordeaux]
2 University of Birmingham [Birmingham]
3 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
4 Pôle de Biologie Pathologie Génétique [CHU Lille]
5 Hôpital de Hautepierre [Strasbourg]
6 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
7 Hôpital Côte de Nacre [CHU Caen]
8 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
9 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
10 Hôpital Saint-Louis
11 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
12 Hôpital Robert Debré
13 Hôpital Universitaire de Caen
14 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
15 CHU Amiens-Picardie
16 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
17 CHU Dijon
18 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
19 Hôtel-Dieu de Nantes
20 Hôpital Haut-Lévêque [CHU Bordeaux]
Eileen Boyle
- Fonction : Auteur
- PersonId : 772301
- ORCID : 0000-0001-8791-1744
- IdRef : 183072863
Loïc Renaud
- Fonction : Auteur
- PersonId : 786409
- ORCID : 0000-0001-7213-9464
Aurore Perrot
- Fonction : Auteur
- PersonId : 769019
- IdRef : 139420215
Philippe Moreau
- Fonction : Auteur
- PersonId : 759214
- ORCID : 0000-0003-1780-8746
Hervé Avet-Loiseau
- Fonction : Auteur
- PersonId : 948224
- ORCID : 0000-0002-3050-0140
Stephen Harding
- Fonction : Auteur
Xavier Leleu
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- Fonction : Auteur correspondant
- PersonId : 989084
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Résumé
Automated serum heavy + light chain (HLC) immunoassays can measure the intact immunoglobulins of each light chain type separately. We though to compare HLC assays with electrophoretic techniques in determining International Myeloma Working Group (IMWG) response criteria. 114 myeloma patients from 2 trials were included. HLC measurements were made utilizing archived sera and response assessments compared with those based on electrophoretic analysis at the time of the trials. Assessments at ∼90 days and maximal response were compared as was the power of the 2 techniques for predicting later responses, overall survival, and progression. The kappa statistic indicated good agreement between the 2 methods for determining IMWG response criteria, although HLC measurements might give better predictions of subsequent responses and frequently gave an earlier indication of change. HLC measurements could represent an alternative to electrophoretic techniques in determining IMWG response. Validation with a greater range of patient responses is needed for confirmation.