Expert opinion on immunotherapy induced diabetes - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Annales d'Endocrinologie Année : 2018

Expert opinion on immunotherapy induced diabetes


Immunotherapy often incurs side-effects, mainly involving the skin, digestive tract and endocrine system. The most frequent endocrine side-effects involve the pituitary and thyroid glands. Cases of insulin-dependent diabetes, whether autoimmune or not (type 1 or 1B) have been reported with PD-1/PD-L1 inhibitors, alone or in association with anti-CTLA-4 antibodies, and were systematically associated with sudden-onset insulinopenia, frequently leading to ketoacidosis or fulminant diabetes, requiring first-line insulin therapy. This adverse effect has not so far been reported with anti-CTLA-4 monotherapy.

Mots clés

Fichier non déposé

Dates et versions

hal-01945900 , version 1 (05-12-2018)



Sarra Smati, Perrine Buffier, Benjamin Bouillet Bouillet, Françoise Archambeaud, Bruno Vergès, et al.. Expert opinion on immunotherapy induced diabetes. Annales d'Endocrinologie, 2018, 79 (5), pp.545-549. ⟨10.1016/j.ando.2018.07.006⟩. ⟨hal-01945900⟩
28 Consultations
0 Téléchargements



Gmail Facebook X LinkedIn More