B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS - Université de Bourgogne
Article Dans Une Revue Cancer Epidemiology, Biomarkers and Prevention Année : 2022

B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

1 Beckman Research Institute of the City of Hope
2 UNSW - University of New South Wales [Sydney]
3 NCI-NIH - National Cancer Institute [Bethesda]
4 Mayo Clinic [Rochester]
5 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
6 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
7 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
8 UC Irvine - University of California [Irvine]
9 UAB - University of Alabama at Birmingham [ Birmingham]
10 UCLA - University of California [Los Angeles]
11 UC San Francisco - University of California [San Francisco]
12 Macquarie University [Sydney]
13 Statens Serum Institut [Copenhagen]
14 British Columbia Cancer Research Centre [British Columbia, Canada]
15 China Academy of Chinese Medical Sciences
16 HMS - Harvard Medical School [Boston]
17 Emory University [Atlanta, GA]
18 Hadassah Hebrew University Medical Center [Jerusalem]
19 University of York [York, UK]
20 City of Hope Comprehensive Cancer Center [Duarte]
21 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
22 CHU Dijon
23 University of Cagliari
24 MMCI - Masaryk Memorial Cancer Institute
25 SFU.ca - Simon Fraser University = Université Simon Fraser
26 Drexel University
27 UC Berkeley - University of California [Berkeley]
28 SBU - Stony Brook University [SUNY]
29 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
30 The University of Sydney
31 Brown University
32 CRESS - Centre for Research in Earth and Space Science [Toronto]
33 BPH - Bordeaux population health
34 EPICENE - Cancer environnement
35 Institut Bergonié [Bordeaux]
36 Karolinska Institutet [Stockholm]
Tongzhang Zheng
  • Fonction : Auteur

Résumé

BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
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hal-03697882 , version 1 (17-06-2022)

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Sophia S. Wang, Claire M. Vajdic, Martha S. Linet, Susan L. Slager, Jenna Voutsinas, et al.. B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS. Cancer Epidemiology, Biomarkers and Prevention, 2022, 31 (5), pp.1103-1110. ⟨10.1158/1055-9965.Epi-21-0875⟩. ⟨hal-03697882⟩
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