Climate change is affecting grape yield, composition and wine quality. As a result, the geography of wine production is changing. In this Review, we discuss the consequences of changing temperature, precipitation, humidity, radiation and CO2 on global wine production and explore adaptation strategies. Current winegrowing regions are primarily located at mid-latitudes (California, USA; southern France; northern Spain and Italy; Barossa, Australia; Stellenbosch, South Africa; and Mendoza, Argentina, among others), where the climate is warm enough to allow grape ripening, but without excessive heat, and relatively dry to avoid strong disease pressure. About 90% of traditional wine regions in coastal and lowland regions of Spain, Italy, Greece and southern California could be at risk of disappearing by the end of the century because of excessive drought and more frequent heatwaves with climate change. Warmer temperatures might increase suitability for other regions (Washington State, Oregon, Tasmania, northern France) and are driving the emergence of new wine regions, like the southern United Kingdom. The degree of these changes in suitability strongly depends on the level of temperature rise. Existing producers can adapt to a certain level of warming by changing plant material (varieties and rootstocks), training systems and vineyard management. However, these adaptations might not be enough to maintain economically viable wine production in all areas. Future research should aim to assess the economic impact of climate change adaptation strategies applied at large scale.