A valuable tool for comprehending and characterizing climate patterns on a global scale is the Köppen–Geiger climate classification system. When it comes to wine production, the climate of a region plays an essential role in determining whether specific grape varieties can be cultivated, largely determining the style of wine that can be made, and influencing the consistency of overall wine quality. In this study, the application of the Köppen–Geiger classification system to the latest Coupled Model Intercomparison Project (CMIP6) experiments has been explored. To establish a baseline for the historical period (1970–2000), the WorldClim dataset was used alongside a selection of an ensemble of 14 Global Climate Models. The evaluation of climate variability across winemaking regions is conducted by considering future climate projections from 2041 to 2060, which are based on different anthropogenic radiative forcing scenarios (Shared Socioeconomic Pathways, SSP2–4.5, and SSP5–8.5). The results are the most comprehensive documentation of both the historical climate classifications for most wine regions worldwide and the potential changes in these classifications in the future. General changes in climate types are projected to occur largely in a significant shift from a warm summer climate to a hot summer climate in temperate and dry zones worldwide (climate types C and B, respectively). This shift poses challenges for grape cultivation and wine production. The grape development process can be significantly affected by high temperatures, which could result in early ripening and changes in the grape berry’s aromatic compounds. As regions transition and experience different climates, wine producers are required to adapt their vineyard management strategies by implementing suitable measures that can effectively counter the detrimental impacts of abiotic stresses on grape quality and vineyard health. These adaptation measures may include changes in canopy and soil management, using different variety-clone-rootstock combinations, adopting irrigation methods, or shifting into other microclimatic zones, among other effective techniques. To ensure long-term sustainability, wine producers must consider the climatic change projections that are specific to their region, allowing them to make more informed decisions about vineyard management practices, reducing risks, and ultimately making the wine industry more resilient and adaptive to the ongoing effects of climate change.