Use of bioassays to assess hazard of food contact material extracts: State of the art - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Food and Chemical Toxicology Année : 2017

Use of bioassays to assess hazard of food contact material extracts: State of the art

Isabelle Séverin
Emilie Souton
  • Fonction : Auteur
Laurence Dahbi
  • Fonction : Auteur

Résumé

This review focuses on the use of in vitro bioassays for the hazard assessment of food contact materials (FCM) as a relevant strategy, in complement to analytical methods. FCM may transfer constituents to foods, not always detected by analytical chemistry, resulting in low but measurable human exposures. Testing FCM extracts with bioassays represents the biological response of a combination of substances, able to be released from the finished materials. Furthermore, this approach is particularly useful regarding the current risk assessment challenges with unpredicted/unidentified non-intentionally added substances (NIAS) that can be leached from the FCM in the food. Bioassays applied to assess hazard of different FCM types are described for, to date, the toxicological endpoints able to be expressed at low levels; cytotoxicity, genotoxicity and endocrine disruption potential. The bioassay strengths and relative key points needed to correctly use and improve the performance of bioassays for an additional FCM risk assessment is developed. This review compiles studies showing that combining both chemical and toxicological analyses presents a very promising and pragmatic tool for identifying new undesirable NIAS (not predicted) which can represent a great part of the migrating substances and/or "cocktail effect".
Fichier non déposé

Dates et versions

hal-01560265 , version 1 (11-07-2017)

Identifiants

Citer

Isabelle Séverin, Emilie Souton, Laurence Dahbi, Marie-Christine Chagnon. Use of bioassays to assess hazard of food contact material extracts: State of the art. Food and Chemical Toxicology, 2017, 105, pp.429-447. ⟨10.1016/j.fct.2017.04.046⟩. ⟨hal-01560265⟩
62 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More