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Article Dans Une Revue Frontiers in Immunology Année : 2018

Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions


The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophagosomes in effector CD4 T cells, further work has shown that not only autophagy levels are modulated in CD4 T cells in response to environmental signals but also that autophagy critically affects the biology of these cells. Mouse models of autophagy deletion in CD4 T cells have indeed shown that autophagy is essential for CD4 T cell survival and homeostasis in peripheral lymphoid organs. Furthermore, autophagy is required for CD4 T cell proliferation and cytokine production in response to T cell receptor activation. Recent developments have uncovered that autophagy controls CD4 T cell differentiation and functions. While autophagy is required for the maintenance of immunosuppressive functions of regulatory T cells, it restrains the differentiation of T(H)9 effector cells, thus limiting their antitumor and pro-inflammatory properties. We will here discuss these findings that collectively suggest that therapeutic strategies targeting autophagy could be exploited for the treatment of cancer and inflammatory diseases.



Dates et versions

hal-01818431 , version 1 (19-06-2018)



Elise Jacquin, Lionel Apetoh. Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions. Frontiers in Immunology, 2018, 9, pp.1023. ⟨10.3389/fimmu.2018.01023⟩. ⟨hal-01818431⟩
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