Management and Outcomes of Pancreatic Cancer in French Real-World Clinical Practice - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2022

Management and Outcomes of Pancreatic Cancer in French Real-World Clinical Practice

Résumé

Background: Our objective was to describe real-world patterns of care and outcomes in pancreatic cancer. Methods: 912 patients diagnosed with pancreatic cancer from 2014 to 2017 were registered by the population-based cancer registry of Burgundy (France). Progression-free and net survival were estimated. Results: at diagnosis, 52% of tumors were associated with metastases. Among the 20% of patients fulfilling resectability criteria, half of those aged 75–84 years and none of those ≥85 years actually underwent resection. Age was not associated with 3-year observed survival in patients who underwent resection. Overall, 77% of patients aged <75 years, 55% of those aged 75–84 years and 8% of those ≥85 years received chemotherapy. Among patients who were offered chemotherapy, 73% of those aged ≥85 years refused. Chemotherapy toxicity was higher with Gemcitabine_Oxaliplatin/Gemcitabine_Abraxane and FOLFIRINOX than with Gemcitabine alone. Patients resected after induction FOLFIRINOX and those treated with adjuvant Gemcitabine presented the lowest risk of progression. Three-year net survival was 35% in patients with non-metastatic resectable tumors and under 10% for other patients. Conclusions: Only half of patients aged 75–84 years with a resectable tumor actually underwent resection. Two thirds of patients aged ≥85 years refused chemotherapy, thus underlining the need to expand geriatric assessments.
Fichier principal
Vignette du fichier
JOOSTE_2022.pdf (1.17 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04245684 , version 1 (17-10-2023)

Licence

Paternité

Identifiants

Citer

Valérie Jooste, Leila Bengrine-Lefevre, Sylvain Manfredi, Valérie Quipourt, Pascale Grosclaude, et al.. Management and Outcomes of Pancreatic Cancer in French Real-World Clinical Practice. Cancers, 2022, 14 (7), pp.1675. ⟨10.3390/cancers14071675⟩. ⟨hal-04245684⟩
14 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More