Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Molecular metabolism Année : 2014

Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice

Résumé

Pairing the selective estrogen receptor modulator bazedoxifene (BZA) with estrogen as a tissue-selective estrogen complex (TSEC) is a novel menopausal therapy. We investigated estrogen, BZA and TSEC effects in preventing diabetisity in ovariectomized mice during high-fat feeding. Estrogen, BZA or TSEC prevented fat accumulation in adipose tissue, liver and skeletal muscle, and improved insulin resistance and glucose intolerance without stimulating uterine growth. Estrogen, BZA and TSEC improved energy homeostasis by increasing lipid oxidation and energy expenditure, and promoted insulin action by enhancing insulin-stimulated glucose disposal and suppressing hepatic glucose production. While estrogen improved metabolic homeostasis, at least partially, by increasing hepatic production of FGF21, BZA increased hepatic expression of Sirtuin1, PPARα and AMPK activity. The metabolic benefits of BZA were lost in estrogen receptor-α deficient mice. Thus, BZA alone or in TSEC produces metabolic signals of fasting and caloric restriction and improves energy and glucose homeostasis in female mice.
Fichier principal
Vignette du fichier
kim_2014_vol3_pp177_mol.metab_{8B5CA965-F186-4DD7-AABD-72B56F25403B}.pdf (6.64 Mo) Télécharger le fichier
Origine : Accord explicite pour ce dépôt
Loading...

Dates et versions

hal-01186418 , version 1 (24-08-2015)

Identifiants

Citer

Jun Ho Kim, Matthew S. Meyers, Saja S. Khuder, Simon L. Abdallah, Harrison T. Muturi, et al.. Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. Molecular metabolism, 2014, 3 (2), pp.177-190. ⟨10.1016/j.molmet.2013.12.009⟩. ⟨hal-01186418⟩
100 Consultations
212 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More