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Article Dans Une Revue Dalton Transactions Année : 2014

Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics

Résumé

Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × Φ F) and relaxivity R 1) and fluorescence confocal/biphoton microscopy studies were conducted. † Electronic supplementary information (ESI) available: Experimental characterization, NMR and photophysical spectra. See

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Chimie
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Dates et versions

hal-03263267 , version 1 (17-06-2021)

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Yann Bernhard, Pascale Winckler, Jean-Marie Perrier-Cornet, Richard A Decréau. Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics. Dalton Transactions, 2014, 44 (7), pp.3200 - 3208. ⟨10.1039/c4dt03536d⟩. ⟨hal-03263267⟩
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